I had much difficulty to get one of the sufferers, who was sixty years old, to swallow the first few spoonfuls. He was plunged into a lethargic insensibility differing in no respect from complete apoplexy; his teeth were closely set. Those whom I had ordered to administer the mixture had given it up, after several useless attempts; and in all probability the old man would have sunk, had I not had the patience to hold, for some hours, against his teeth the back of the blade of a small silver knife, so as to profit by the few moments when the teeth were a little less firmly clenched. I used some force to make the blade act as a wedge, and after a while opened up a passage to the handle, which, serving as a lever, forced the jaws sufficiently apart to admit the introduction of a spoonful of the emetic. It was not, however, until fully two hours had passed that the patient, having undoubtedly swallowed the necessary dose, began to vomit, with strenuous efforts and frightful cries. This was at midnight. Four in the morning arrived before, after numerous alternations of vomiting and profound lethargy, he began to speak, and then like a man in delirium. After the first vomit, which was inconsiderable, the convulsions of his whole body were so very violent as to require four men to hold him, while I continued to make use of my knife as at first. Nor did I desist until I was satisfied that his stomach had been sufficiently cleansed. After this, I applied two strong blisters to the back of his legs. As these acted, the purging subsided, and at the end of twenty-four hours it had passed away entirely, the invalid finding himself as well as could be expected after sustaining so severe a shock. The other patients, who were not in so much danger, experienced twitchings and tremblings in the face, which quite disfigured them; the brain seemed a blank; though awake, they felt as in a dream, and their visions were most frightful. It is evident, from these particulars, that mushroom-poisoning specially affects the encephalic nervous system, and that the best remedies are emetics and antispasmodics. In our present ignorance of what are the poisonous principles in the _Amanita_, we can adopt no other method than a chemical neutralisation. AGARICUS CÆSAREUS, OR IMPERIAL MUSHROOM.