In presenting the hypothesis of pangenesis Darwin begins by enumerating the different kinds of sexual and asexual processes of reproduction, for which he hopes to offer a provisional explanation. Here we find mentioned various methods of budding and self-division, regeneration, parthenogenesis, sexual reproduction, and the inheritance of acquired characters. It is with the last only that we are here chiefly concerned; in fact, the need of an hypothesis _of this sort_ to explain the other kinds of inheritance is by no means evident. There are, however, two other phenomena, besides that of the supposed inheritance of acquired characters, to which the hypothesis of pangenesis might appear to apply specially, namely, the effect of foreign pollen on the tissues of the mother plant, and the supposed influence of the union with the first male on the subsequent young (telegony). It is, however, far from being shown that any influence of this latter kind really occurs, despite the fact that it is generally believed in by breeders. It is important to observe that Darwin proposes to explain on the hypothesis of pangenesis, not only the inheritance of characters acquired through use, but also the decrease of structures through disuse; and this applies, not only to the structure, but to function as well, as when the intelligence of the dog is explained through his association with man, and the tameness of the domestic rabbits through their long confinement. In the following quotation these points are referred to: “How can the use or disuse of a particular limb or of the brain affect a small aggregate of reproductive cells, seated in a distant part of the body, in such a manner that the being developed from these cells inherits the characters of either one or both parents? Even an imperfect answer to this question would be satisfactory.”