Reflecting upon the disagreeable necessity we seemed to lie under of confining this putrid matter in the intestines, lest the evacuation should destroy the _vis vitae_ before there was time to correct its bad quality, and overcome its bad effects, by the means we were using; I considered, that, if this putrid ferment could be more immediately corrected, a stop would probably be put to the flux, which seemed to arise from, or at least to be encreased by it; and the _fomes_ of the disease would likewise be in a great measure removed. I thought nothing was so likely to effect this, as the introduction of fixed air into the alimentary canal, which, from the experiments of Dr. Macbride, and those you have made since his publication, appears to be the most powerful corrector of putrefaction hitherto known. I recollected what you had recommended to me as deserving to be tried in putrid diseases, I mean, the injection of this kind of air by way of clyster, and judged that in the present case such a method was clearly indicated. The next morning I mentioned my reflections to Dr. Hird and Dr. Crowther, who kindly attended this young gentleman at my request, and proposed the following method of treatment, which, with their approbation, was immediately entered upon. We first gave him five grains of ipecacuanha, to evacuate in the most easy manner part of the putrid _colluvies_: he was then allowed to drink freely of brisk orange-wine, which contained a good deal of fixed air, yet had not lost its sweetness. The tincture of bark was continued as before; and the water which he drank along with it, was impregnated with fixed air from the atmosphere of a large vat of fermenting wort, in the manner I had learned from you. Instead of the astringent clyster, air alone was injected, collected from a fermenting mixture of chalk and oil of vitriol: he drank a bottle of orange-wine in the course of this day, but refused any other liquor except water and his medicine: two bladders full of air were thrown up in the afternoon.