Mr. W----, aged forty-four years, corpulent, inactive, with a short neck, and addicted to habits of intemperance, was attacked on the 7th of July 1772, with symptoms which seemed to threaten an apoplexy. On the 8th, a bilious looseness succeeded, with a profuse hoemorrhage from the nose. On the 9th, I was called to his assistance. His countenance was bloated, his eyes heavy, his skin hot, and his pulse hard, full, and oppressed. The diarrhoea continued; his stools were bilious and very offensive; and he complained of griping pains in his bowels. He had lost, before I saw him, by the direction of Mr. Hall, a surgeon of eminence in Manchester, eight ounces of blood from the arm, which was of a lax texture; and he had taken a saline mixture every sixth hour. The following draught was prescribed, and a dose of rhubarb directed to be administered at night. Rx. _Aq. Cinnam. ten._ oz. j. _Succ. Limon. recent._ oz. ss. _Salis Nitri gr. xij. Syr. e Succo Limon. dr. j. M. f. Haust._ _4tis horis sumendus._ July 11. The _Diarrhoea_ was more moderate; his griping pains were abated; and he had less stupor and dejection in his countenance. Pulse 90, not so hard or oppressed. As his stools continued to be foetid, the dose of rhubarb was repeated; and instead of simple cinnamon-water, his draughts were prepared with an infusion of columbo root. 12. The _Diarrhoea_ continued; his stools were involuntary; and he discharged in this way a quantity of black, grumous, and foetid blood. Pulse hard and quick; skin hot; tongue covered with a dark fur; abdomen swelled; great stupor. Ten grains of columbo root, and fifteen of the _Gummi rubrum astringens_ were added to each draught. Fixed air, under the form of clysters, was injected every second or third hour; and directions were given to supply the patient plentifully with water, artificially impregnated with mephitic air. A blister was also laid between his shoulders. 13. The Diarrhoea continued, with frequent discharges of blood; but the stools had now lost their foetor. Pulse 120; great flatulence in the bowels, and fulness in the belly. The clysters of fixed air always diminished the tension of the _Abdomen_, abated flatulence, and made the patient more easy and composed for some time after their injection. They were directed to be continued, together with the medicated water. The nitre was omitted, and a scruple of the _Confect. Damocratis_ was given every fourth hour, in an infusion of columbo root. 14. The Diarrhoea was how checked, His other symptoms continued as before. Blisters were applied to the arms; and a drachm and a half of the _Tinctura Serpentariae_ was added to each draught.