"The Act of 1876 expressly forbids its use as an anæsthetic. When it is used, it must be supplemented with some other drug to relieve pain. A good deal of misconception exists as to the actual physiological effect of curare. Claude Bernard believed that it did not in any way affect the sensory nerves, and he described in theatrical terms the animal as being unable to stir, but suffering horrible torture. It is pretty certainly known now that Claude Bernard was wrong, and that, though curare acts first upon the motor nerves, it also, though less rapidly, paralyses the sensory nerves.... Probably the truth is, that, like all other nerve-poisons, the effect of curare varies with the dose. The muscular nerves are the first affected, then the sensory, and finally the central nervous system. As a matter of fact, however, morphia or some other narcotic is always given in addition to curare when it is used in laboratory work in England." III.--LATEST REPORT (1905) OF INSPECTORS UNDER THE ACT (The various tables of names, places, &c., and the references to them, which are contained in this Report, need not be reprinted here. The Report, and other papers relating to the Act, may be bought for a few pence from Wyman & Sons, Ltd., Fetter Lane, E.C.) * * * * * ENGLAND AND SCOTLAND _April 17th, 1906._ SIR,--I have the honour to submit the following Report on Experiments performed in England and Scotland during the Year 1905, under the Act 39 & 40 Vict. c. 77.... Six new places were registered for the performance of experiments, and one place was removed from the register during the year. All licensees were restricted to the registered place or places specified on their licenses, with the exception of those who were permitted to perform inoculation experiments in places other than a "registered place," with the object of studying outbreaks of disease occurring in remote districts or under circumstances which render it impracticable to perform the experiment in a "registered place." The total number of licensees was 381. Reports have been furnished by (or, in a few exceptional cases, on behalf of) these licensees in the form required by the Secretary for State. The reports show that 122 licensees performed no experiments. The numbers given above include 22 licensees whose licences expired on February 28, 1905, and who returned no experiments in 1905. Tables I., II., and III. afford evidence,-- 1. That licences and certificates have been granted and allowed only upon the recommendation of persons of high scientific standing; 2. That the licensees are persons who, by their training and education, are fitted to undertake experimental work and to profit by it; 3. That all experimental work has been conducted in suitable places.