Is it possible, after so many decisive investigations into the origin of the elements of animals and vegetables, the use of the alkalies, of lime and the phosphates, any doubt can exist as to the principles upon which a rational agriculture depends? Can the art of agriculture be based upon anything but the restitution of a disturbed equilibrium? Can it be imagined that any country, however rich and fertile, with a flourishing commerce, which for centuries exports its produce in the shape of grain and cattle, will maintain its fertility, if the same commerce does not restore, in some form of manure, those elements which have been removed from the soil, and which cannot be replaced by the atmosphere? Must not the same fate await every such country which has actually befallen the once prolific soil of Virginia, now in many parts no longer able to grow its former staple productions--wheat and tobacco? In the large towns of England the produce both of English and foreign agriculture is largely consumed; elements of the soil indispensable to plants do not return to the fields,--contrivances resulting from the manners and customs of English people, and peculiar to them, render it difficult, perhaps impossible, to collect the enormous quantity of the phosphates which are daily, as solid and liquid excrements, carried into the rivers. These phosphates, although present in the soil in the smallest quantity, are its most important mineral constituents. It was observed that many English fields exhausted in that manner immediately doubled their produce, as if by a miracle, when dressed with bone earth imported from the Continent. But if the export of bones from Germany is continued to the extent it has hitherto reached, our soil must be gradually exhausted, and the extent of our loss may be estimated, by considering that one pound of bones contains as much phosphoric acid as a hundred-weight of grain. The imperfect knowledge of Nature and the properties and relations of matter possessed by the alchemists gave rise, in their time, to an opinion that metals as well as plants could be produced from a seed. The regular forms and ramifications seen in crystals, they imagined to be the leaves and branches of metal plants; and as they saw the seed of plants grow, producing root, stem and leaves, and again blossoms, fruit and seeds, apparently without receiving any supply of appropriate material, they deemed it worthy of zealous inquiry to discover the seed of gold, and the earth necessary for its development. If the metal seeds were once obtained, might they not entertain hopes of their growth?