Again in 1840, after the four years' term of Van Buren, the protégé of Jackson, all eyes turned toward Clay as the coming President. But already he had been twice the nominee and been twice defeated. The anti-slavery element had become a serious factor in party plans. The secretary of the American Anti-Slavery Society in New York wrote Clay: "I should consider the election of a slave-holder to the presidency a great calamity to the country." The slave-holders meantime denounced Clay as an abolitionist. When the Whig national convention met, December 4, 1839, they chose, not Clay, but General William Henry Harrison, a good man and a successful soldier, but a very different man from the popular Clay. The statesman was sorely disappointed. "I am," he said, "the most unfortunate man in the history of parties: always run by my friends when sure to be defeated, and now betrayed for a nomination when I or any one would be sure of an election." His friends throughout the country were grieved and indignant. But Clay supported with all his power the true-hearted old soldier, who, when elected, offered him the first place in the Cabinet, which was declined. Harrison died a month after his inauguration, and John Tyler became President. Clay and Tyler differed constantly, till Clay determined to retire from the Senate. He said: "I want rest, and my private affairs want attention. Nevertheless, I would make any personal sacrifice if, by remaining here, I could do any good; but my belief is I can effect nothing, and perhaps my absence may remove an obstacle to something being done by others." When it became known that Clay would make a farewell address, the Senate chamber was crowded.