Though George III was not on friendly terms with any of his sons, and was careful to keep them, so far as possible, out of England, it was his remaining children that caused him the most serious unhappiness. The Prince of Wales, Frederick, Duke of York, and Ernest, Duke of Cumberland, were so many thorns in the flesh. The conduct of the Prince of Wales need here only be referred to, _en passant_,[284] his behaviour from first to last was marked by no degree of affection or respect for his parents, or, indeed, by any consideration of decency. From an early age, encouraged by his uncle and aunt, the Duke and Duchess of Cumberland, he plunged into debauchery of every kind. While still in his teens, his _liaisons_ were notorious, his losses at the cardtable considerable, and his extravagance gigantic. When he came of age he threw himself into the arms of the Opposition, and soon was at open enmity with his father. What might have happened if George III had been a wise parent, or even possessed of ordinary commonsense, cannot be said, but his methods of strict repression and his want of sympathetic insight alienated his boys one by one. Even into the Journal of Mrs. Papendiek, that undiscriminating eulogiser of the King and Queen, has crept one example of the gracelessness of the monarch, when, after his illness, wine had been recommended to him in very small quantities to assist digestion. "As his Majesty had never taken it he doubted its efficacy. The Prince of Wales sent a few bottles of the finest Madeira, so he said, that the island had ever produced, and proposed tasting it with the King when the family dined at four o'clock. The King thanked his Royal Highness, but said he hoped for the credit of his gentlemen of the wine cellar, and for the pleasure of those who partook of such indulgences, that the best was always provided. For himself it would be his last treat, as he was sure it did him more harm than good."[285] [284] The present writer has given a detailed sketch of the life of the Prince of Wales in _The First Gentleman of Europe_. [285] Papendiek: _Court and Private Life_.