When Giulio de’ Medici, the illegitimate son of Giuliano, ascended the papal throne as Clement VII., Filippo Strozzi hastened to Rome to congratulate his wife’s kinsman, and to beg for a cardinal’s hat for his eldest son Piero. Not long afterwards the Pope was forced to take refuge in Castel Sant’Angelo, and had to sue for peace with Charles V. A hostage was demanded, and Filippo, sorely against his will, was chosen and went as a prisoner to Naples with Don Ugo di Moncada. Needless to say Clement kept none of his promises and Filippo was in some danger of losing his head. A shift in politics saved him just as his wife Clarice reached Rome, where she spoke some hard words to the Pope. Soon afterwards Clement for the second time sought refuge in Castel Sant’Angelo and Rome was sacked by the Constable de Bourbon. “Never,” writes old Varchi, “was chastisement so tremendous inflicted, nor was it ever more richly deserved.” Filippo and his wife left two days before the catastrophe for Civitavecchia and sailed for Pisa, where messengers met them from the Cardinal of Cortona, who was governing Florence for the Medici, and from Niccolò Capponi, brother-in-law of Filippo and head of the anti-Medicean party. Strozzi had need of all his prudence and astuteness at this juncture. Clarice urged him to proceed at once to Florence, where his influence would be supreme on whichever side he chose to use it. After much pondering he decided to send her to “try the difficult ford” as his brother Lorenzo puts it, and Clarice, who had always been he continues, “high-spirited even beyond what was prudent,” started for Florence at once. Her first interview was with Niccolò Capponi and others of the “Ottimati” or patrician party, to whom she promised her husband’s and her own help in expelling her kinsmen the Medici. She was then carried in her litter to the Palazzo Medici (now Palazzo Riccardi), where the Cardinal Ridolfi and young Ippolito de’ Medici met her on the staircase and conducted her into the room next the chapel where sat the Cardinal-Governor. He rose to salute her and, as Varchi writes, she said to him: “Ah Monsignore, Monsignore, whither have you led us. Does it seem to you that your past and present conduct is in any way similar to that practised by my ancestors?” After setting forth how they had always obeyed the will of the people, she turned to the two lads, Ippolito and Alessandro de’ Medici, and advised them to think of their own safety, for which she naturally felt more anxiety than the cardinal.