Pasteur made his first communication on this subject to the Academy of Sciences in September, 1865. It raised a cloud of criticism. Here, forsooth, was a chemist rashly quitting his proper _métier_ and presuming to lay down the law for the physician and biologist on a subject which was eminently theirs. 'On trouva étrange que je fusse si peu au courant de la question; on m'opposa des travaux qui avaient paru depuis longtemps en Italie, dont les résultats montraient l'inutilité de mes efforts, et l'impossibilité d'arriver à un résultat pratique dans la direction que je m'étais engagé. Que mon ignorance fut grande au sujet des recherches sans nombre qui avaient paru depuis quinze années.' Pasteur heard the buzz, but he continued his work. In choosing the eggs intended for incubation, the cultivators selected those produced in the successful 'educations' of the year. But they could not understand the frequent and often disastrous failures of their selected eggs; for they did not know, and nobody prior to Pasteur was competent to tell them, that the finest cocoons may envelope doomed corpusculous moths. It was not, however, easy to make the cultivators accept new guidance. To strike their imagination, and if possible determine their practice, Pasteur hit upon the expedient of prophecy. In 1866 he inspected, at St. Hippolyte-du-Fort, fourteen different parcels of eggs intended for incubation. Having examined a sufficient number of the moths which produced these eggs, he wrote out the prediction of what would occur in 1867, and placed the prophecy as a sealed letter in the hands of the Mayor of St. Hippolyte. In 1867 the cultivators communicated to the mayor their results. The letter of Pasteur was then opened and read, and it was found that in twelve out of fourteen cases there was absolute conformity between his prediction and the observed facts. Many of the groups had perished totally; the others had perished almost totally; and this was the prediction of Pasteur. In two out of the fourteen cases, instead of the prophesied destruction, half an average crop was obtained. Now, the parcels of eggs here referred to were considered healthy by their owners. They had been hatched and tended in the firm hope that the labour expended on them would prove remunerative. The application of the moth-test for a few minutes in 1866, would have saved the labour and averted the disappointment. Two additional parcels of eggs were at the same time submitted to Pasteur. He pronounced them healthy; and his words were verified by the production of an excellent crop. Other cases of prophecy still more remarkable, because more circumstantial, are recorded in Pasteur's work.