During the reign of Ferdinand and Isabella, pilgrims still flocked in hundreds of thousands to the tomb of St. James in Galicia; and the king and queen, knowing how poor was the accommodation provided for pilgrims at Santiago, commanded that a commodious inn should be constructed close to the cathedral, where pious pilgrims might find shelter and the sick be nursed. It was just after their conquest of Granada that Ferdinand and Isabella, in 1492, decreed that an annual sum of money should be devoted as a thankoffering, one-third for commemoration services to be held at Santiago Cathedral, one-third for the building expenses of the cathedral, and one-third for the relief of the poor, who would be cared for in the hospital they had commanded to be built. The sum of money in question was to be raised by levying a tribute of a bushel of grain on every pair of oxen, horses, mules, or asses used in agriculture by the Moors or Christians.[173] The foundation of the hospital may be said to date from that year, so pregnant with consequences, in which Columbus discovered the New World, and in which Spain not only became for the first time in her history a single and united kingdom, but laid the foundations of her widespread empire to which historians have given the name of Greater Spain. It was not, however, till 1499 that Ferdinand and Isabella authorised the Dean of Santiago, Don Diego de Muros, to start the building of the hospital.[174] [Illustration: ENTRANCE TO THE ROYAL HOSPITAL, SANTIAGO] The work began in good earnest in the year 1501, and the building was ready to receive the first inmates within ten years from that date. At the time of its completion the _Hospital Real_ was the finest establishment of its kind in the world, and it is still regarded as an important example of the Renaissance style of architecture. Molina, writing in 1550, said, “I believe that the hospital is so well known in every part of the world, that all I can say about it will be readily credited. In the three large wards there are few days when there are less than two hundred sick people, especially in Jubilee years, and every patient is treated with as much care as if the hospital had only been erected for his particular benefit. This hospital is one of the great things of the earth. Apart from its sumptuousness and the regal grandeur of its architecture, it is a marvellous thing to feel its size, the multitude of its officials, their diligence, the zeal of the attendants, the cleanliness of the linen, the care taken about the cooking, the perfect order of the routine ... the assiduity of the doctors--in short, one may with reason regard it as a crowning glory of Christendom.”