The imperious Paul V. was still the reigning Pope, and his good will towards Galileo would certainly only have lasted so long as he was entirely submissive. His dialectic reply, which was pervaded by cutting irony aimed at a father of the order of Jesuits, even sometimes making him appear ridiculous, could not have been much to the taste of a Pope to whom the inviolability of the Church and her ministers was all in all. It is characteristic of this pontiff that, as appears from the negotiations with James I., he seriously claimed the right of deposing kings, and called every attempt to make him relinquish this claim “a heretical proceeding,” and pronounced the writings of some Venetian ecclesiastics who disputed it, to be worse than Calvinistic. Just as this stern pontiff was gathered to his fathers (16th January, 1621), in consequence of an attack of apoplexy on the occasion of the celebration of the victory on the Weissenberg, and the good-natured and infirm old man, Gregory XV., ascended the papal chair, Galileo sustained a blow which was most disastrous to him. This was the death, on 28th February, 1621, of his kind protector and patron, Cosmo II. The protection of an energetic prince who sincerely respected him, which he had hitherto enjoyed, was replaced by the uncertain favour of a feminine government, as the widowed Grand Duchess, whose tendencies were thoroughly Romish, assumed the regency for Ferdinand II., who was still in his minority. Under these circumstances Galileo was but little inclined to bring out his reply; and perhaps the time when they were founding the Propaganda at Rome, and enrolling Loyola and Xavier among the saints, did not seem very opportune. From the new Pope personally there was nothing to fear. The phlegmatic little man, who was so bowed down by age and sickness that those about him often feared to lay complicated business matters before him, lest he should entirely break down, was certainly not likely to inspire awe; besides, Gregory had expressed himself to Ciampoli very favourably of Galileo.[169] But the Pope’s infirmities made it all the more necessary to proceed with caution; for they allowed the Romish administration to exercise full sway. And the man who guided it with almost sovereign authority was the Pope’s nephew, Cardinal Lodovico Lodovisi, a former pupil and therefore zealous friend of the Jesuits. Nevertheless Galileo’s adherents, and especially his clerical friends at Rome, considered it absolutely necessary to publish his reply as soon as possible, with the precautions before mentioned, because his opponents construed his silence into a triumph for Grassi and the Aristotelian school.[170] Prince Cesi, Mgrs. Cesarini and Ciampoli—the latter of whom meanwhile had become Secretary of the Papal Briefs to Gregory XV., a post which he also held under his successor, Urban VIII., until he fell into disgrace about Galileo—urged him repeatedly to finish his reply.[171]