It is also to this obscurity of the vital properties of the fibro-cartilages, to their want of energy, that must undoubtedly be referred the rareness of diseases of these organs. I know but few of the organic systems in the economy, which are more rarely affected than that of the fibro-cartilages of the nose, of the ears, the trachea, &c. Gangrene attacks them with difficulty; they are scarcely altered by it, whilst the soft parts which surround them are all already black. We know but little of the kind of fluid they form in their suppuration. The formation of pus appears to be even very rare in them, owing to their want of vital activity. As these organs are hardly ever diseased, we can with difficulty know their sympathies; I am unable to cite an example of them. ARTICLE FOURTH. DEVELOPMENT OF THE FIBRO-CARTILAGINOUS SYSTEM. I. _State of this System in the first age._ In the first periods of existence, the articular fibro-cartilages are much developed, which appears to be the effect of the size of the articulations at this period. In fact, as the extremities of the bones are larger in proportion, whilst they are cartilaginous, than when they are in the osseous state, the articulations are also proportionally larger, and the organs they contain more developed. The fibro-cartilages of the grooves, which are found almost all, as we know, situated at the extremities of the long bones, are not, in the first age distinct from the cartilages of ossification, which then form these extremities. Confounded with them, they exhibit no line of demarcation when we cut the lines at that place. This state continues until complete ossification; then the fibro-cartilages of the grooves remain insulated like the cartilages of the osseous extremities. The interposed gelatinous portion appears to predominate, in childhood, over the fibrous portion in the articular fibro-cartilages and in those of the grooves. It is remarkable in the intervertebral substances, in which this kind of mucilage which occupies the centre, is as to quantity in the inverse ratio of the age, and in which the fibres are also more developed. On the pubis, the whole is almost homogeneous in the fœtus; the transverse fibres do not become very apparent till a more advanced age. The articulations of the knee, the jaw, &c. have in their fibro-cartilages, the same arrangement. Ebullition extracts from them then a much greater quantity of gelatine; they have more the smooth appearance of the cartilages. The membranous fibro-cartilages are in general developed early, those of the ear, the eyes and the nose especially. We see them very evident in the fœtus. I have observed in two acephalous infants, that, like all the other parts of the face, they were of a remarkable size, and much greater than that of the ordinary state. Besides, the whole fibro-cartilaginous system is, in the fœtus, extremely soft, supple and unresisting.