2d. There are other wrinkles which are owing also to the motions, but not to those of the subjacent muscles. There are those of the sole of the foot, and especially those of the palm of the hand. There is not there any sub-cutaneous muscle adhering to the skin, except the small palmar muscle, which has no agency in these wrinkles that are formed at the places where the skin is constantly folded in flexion. Thus there are many of them about all the articulations of the phalanges. In the palm of the hand, we see three principal ones, one at the base of the thumb, produced by the motion of opposition, another at the anterior part of the palm, occasioned by the flexion of the four last phalanges which are bent towards the thumb, and the third is found in the middle of the palm. The dermis is folded between these depressed lines, in the motions in which the hand is hollowed. Many other small folds corresponding with less evident and less frequent motions, cut these at different angles. On the back of the foot and hand, there are many wrinkles about each articulation of the phalanges, when they are extended. They disappear in flexion, and are owing to this, that nature, on account of the motions, has made the skin more loose at this place, and broader in proportion to the parts it covers. About most of the articulations, there are analogous folds, but they are much less evident, because the skin adheres less to the neighbouring parts. Upon the whole trunk, the arm, the fore-arm, the thigh and the leg, we see no depressions but those from the muscular prominences. 3d. There is a third species of wrinkles, or rather cutaneous impressions, which are not very evident, found especially on the sole of the foot and the palm of the hand and which we easily distinguish from the preceding; they are those which indicate the rows of the papillæ. The surface of the trunk presents hardly any thing similar. 4th. Finally, there are the wrinkles of old age, which are of a wholly different nature. The sub-cutaneous fat having in part disappeared, the skin becomes too large for the parts it covers; now as it has lost with age its contractility of texture, it does not contract, but folds in various directions. Thus where there was the most fat, as on the face, these wrinkles are the most evident, they resemble those that appear on the abdomen after several pregnancies, dropsy, &c. In young people, if emaciation takes place suddenly, the skin contracts, and no wrinkle is formed. II. _Internal Surface of the Dermoid System._