The sulphuric, nitric and muriatic acids act upon the skin, when in contact with it, as upon all the other animal substances. I have remarked however that their action is much slower, especially on the side of the epidermis, though this membrane may have been previously taken off. The first of these acids reduces it easily to a blackish pulp; the others bring it to a pulpy state with more difficulty, even when they are very little weakened; the oxy-muriatic acid produces hardly any effect upon it. Some authors have said that the lapis infernalis produces the same phenomena on the dead as on the living body. I wrapped up in a piece of skin, as in a rag, many fragments of this substance, so that they were in contact with the epidermis; at the end of a day they were reduced to a kind of pap of a yellowish red, by the moisture which they had absorbed. The dermoid texture, crisped and contracted, had not been penetrated; it did not appear even to have been injured on the exterior. In general the action of the alkalies appears to be wholly different during life, and it varies even according to the different degrees of vitality. We know that flaccid and fungous flesh burns much less easily than that which is red and vigorous. It is the same with the acids. Never during life do they produce any thing analogous to that pulp of different colours according to the acids that are employed, which is always after death the result of their action. We know that an alkaline solution, put in contact with the skin, produces a kind of unctuous and slippery feel, which is no doubt owing to the combination of the alkali with the oily deposit of the skin, from which arises a sort of soap. I shall not speak of the tendency of the dermis to combine with tannin, nor of the phenomena of this combination; I should only be able to repeat what others have said upon this point. I will merely remark that it would be very important to try the effects of tannin on the large sub-cutaneous aponeuroses, the texture of which being essentially gelatinous has much analogy with that of the dermis, and which from their extent and delicacy might serve for uses to which the dermoid texture when tanned is less adapted. We know that the tanned skin is no longer what it was in the natural state, and that the substance with which it is then penetrated gives it an artificial consistence. If much tannin has been combined with it, it loses entirely the faculty of acquiring the horny hardness, and becomes brittle; whilst if but little of this substance is added to it, it preserves in part its suppleness and the property of crisping from the action of caloric. I would compare tanned skin to bone penetrated with the phosphate of lime, and that which is not tanned, to the cartilaginous parenchyma from which the acids have removed this phosphate. II. _Parts common to the Organization of the Dermoid System. Cellular Texture._