Dr. Warren writes, under date of 24 Nov., that “In six cases, I have had it applied with satisfactory success, and no unpleasant sequel.” And Dr. Ware (29 Nov.) says: “It was brought into use by a dentist, and is, now, chiefly employed by that class of practitioners. He has taken out a patent for the discovery, and has despatched persons to Europe to secure one there also; so you will soon hear of it, and, probably, have an opportunity of witnessing its effects.” Then follows a long list of operations performed in America—wound up with this postscript: “Dec. 22. Yesterday, we had, ourselves, this new mode of cheating pain put in practice by a master of chirurgery, on our own side of the Atlantic. In the theatre of University College Hospital, Mr. Liston amputated the thigh of a man, previously narcotized by the inhalation of ether vapour. Shortly after being placed on the operating table, the patient began to inhale, and became apparently insensible in the course of two or three minutes. The operation was then commenced, and the limb was removed in, what seemed to us, a marvellously short time—certainly less than a minute; the patient remaining during the incisions and the tying of the arteries, perfectly still and motionless. While the vessels were being secured, on being spoken to, he roused up partially (still showing no signs of pain), and answered questions put to him, in a slow, drowsy manner. He declared to us that at no part of the operation had he felt pain, though he seemed to be partially conscious; he had heard some words, and felt that something was being done to his limb. He was not aware, till told, that the limb was off; and, when he knew it, expressed great gratification at having been saved from pain. The man seemed quite awake when removed from the operating room, and continued so. Everything has since proceeded as usual, and very favourably. “Mr. Liston afterwards performed one of the minor—but most painful operations of surgery—the partial removal of the nail, in _onychia_, on a man similarly narcotised, and with precisely the same result. The patient seemed to feel no pain; and, upon rousing up, after the operation, declared that he had felt none.” _Punch_ found another and more domestic use for this anæsthetic. Patient: “This is really most delightful—a most beautiful dream.” [Picture: Wonderful effects of Ether in a case of a scolding wife]