Bass and Herzberg injected uric acid into the blood of gouty subjects until its content thereof reached 10 mg. per 100 c.c., this without any joint symptoms supervening. The same observers, aspirating _joint fluids_ in _non-gouty_ subjects, noted that the uric acid content was approximately the same as that of the blood. But, in contradistinction thereto, in two _gouty_ subjects, victims of _uræmia_, they found in the joint fluids 18·5 and 20·8 mg. of uric acid, while the blood content was only 10 mg. and 8·2 mg. Furthermore, intravenous injection of uric acid engendered a lesser degree of _uricæmia_ in the gouty—this despite _impaired renal excretion_. To their mind, therefore, the inference was that the _bodily tissues_ in gout display an enhanced capacity for taking up uric acid. Lastly, Walker Hall, discussing the question as to whether any relation obtains between the degree of uricæmia and the onset of acute attacks, observes that, “the evidence is more general than specific.” Thus he reminds us that excessive intake of purin food has sometimes been followed by, or associated with, an acute outbreak. Also, that the leucocytic destruction which occurs during acute lobar pneumonia and after the use of X-rays has occasionally coincided with an acute paroxysm. To this, again, must be added the fact that atophan curtails the duration of acute attacks, apparently by exciting an increased uric acid output. Superficially regarded, these facts might appear to be conclusive; but, as Walker Hall states, it must be recalled that overeating, overdrinking, trauma, mental disturbances, atmospheric vicissitudes, and bacterial infections have also preceded acute outbreaks. To sum up, the main conclusions deducible from the foregoing clinical and experimental findings would appear to be that:— (1) No constant relation has as yet been established between the uric acid content of the blood and acute attacks of gout. (2) No variations in the same apparently herald or accompany typical acute paroxysms. (3) Attacks may occur with a _sub-normal_ uric acid blood content. (4) The tissues of gouty subjects apparently possess an enhanced binding capacity in respect of uric acid. (5) _Given impaired renal excretion in gouty subjects_, the uric acid content of the _joint fluid_ rises markedly, exceeding that of the blood. DISCUSSION OF THE FOREGOING DATA