Gideon Wells states that in normal individuals the tissues contain but little uric acid, and this not in quantities sufficient to permit readily of its isolation in a pure state. Albeit, Wells found considerable amounts of uric acid in the tissues of a young woman who, in sequence to poisoning with HgCl₂, died after complete suppression of urine for nine days. TABLE I.—CONCENTRATION OF URIC ACID IN HUMAN TISSUES AND FLUIDS PER 100 GRAMS OF MATERIAL ------------------+-------+-------+-------+---------+---------+ Case. | E. E. | T. D. | S. H. | M. F. | C. M. | |Uremia.|Uremia.|Uremia.|Diabetes.|Diabetes.| ------------------+-------+-------+-------+---------+---------+ | mg. | mg. | mg. | mg. | mg. | Blood | 15·4 | 14·3 | 17·0 | 0·7 | 0·7 | Pleural fluid | 16·7 | 15·9 | | | | Ascitic fluid | 18·0 | | | | | Pericardial fluid | | 14·3 | 18·0 | | | Subcutaneous fluid| 18·0 | | | | | Spinal fluid | 2·8 | 2·0 | 4·7 | | | Skeletal muscle | 8·0 | 3·9 | 5·8 | 0·7 | 2·6 | Heart muscle | 10·0 | 7·3 | 8·8 | | 1·2 | Liver | 18·0 | 15·6 | 11·5 | | 5·0 | Spleen | 12·6 | 14·3 | 9·1 | | 1·2 | Skin | | 13·0 | | | | ------------------+-------+-------+-------+---------+---------+ ------------------+-----------+---------- Case. | S. T. | H. J. |Amputation.|Pneumonia. ------------------+-----------+---------- | mg. | mg. Blood | 0·7 | Pleural fluid | | Ascitic fluid | | Pericardial fluid | | Subcutaneous fluid| | Spinal fluid | | Skeletal muscle | 2·0 | Heart muscle | | Liver | | 4·0 Spleen | | Trace Skin | | ------------------+-----------+---------- TABLE II.—CONCENTRATION OF URIC ACID IN MISCELLANEOUS HUMAN TISSUES PER 100 GRAMS OF MATERIAL -----------------+------------ Tissue. | Uric acid. -----------------+------------ | mg. Pectoral muscle | 2·5 Uterine muscle | 2·0 Uterine muscle | 2·5 Uterine muscle | 1·2 Mixed tonsils | 1·7 Thyroid | 0·0 -----------------+------------ Again, as before alluded to, Bass and Herzberg found that intravenous injection of uric acid caused less _uricæmia_ in the _gouty_, despite diminished renal excretion. Hence, they concluded that _in gout the retention capacity of the tissues for uric acid is augmented_.