Recently, through the kindness of my colleague Dr. Waterhouse, Dr. Munro and I had again an opportunity of examining the blood in a case of this kind during the _inter-paroxysmal_ period. The subject, a male, had had repeated attacks at the classic site, with subsequent extension to other joints. Multiple tophi were present in both ears, and the crystals of uric acid were demonstrated microscopically. BLOOD COUNT. Red corpuscles 7,364,000 = 147 per cent. Hæmoglobin 74 ” Coloured index 0·5 ” Leucocytes 21,400 DIFFERENTIAL COUNT. Lymphocytes 28·5 per cent. = 6,099 per c. mm. Large mononuclears 2·5 ” = 535 ” Polymorphonuclears 64 ” = 13,696 ” Eosinophiles 3·5 ” = 749 ” Basophiles 1·5 ” = 321 ” The blood picture, it will be seen, is one of erythræmia—a marked leucocytosis, a normal differential percentage count, pronounced secondary anæmia. Da Costa also notes, in a case of gout, erythræmia (7,125,000) with a leucocyte count of 14,000. Ewing, too, records an instance of chronic gout with huge tophi, seen in an acute exacerbation, in which the blood gave a leucocyte count of 21,000 with 70 per cent. hæmoglobin. In another severe instance of subacute type the same observer again met with leucocytosis (15,000). In regard to these interesting blood findings, it is to be cordially hoped that as the somewhat rare opportunities occur they will be taken full advantage of. As to the other general clinical features the _nervous_ system, as might be expected, is often greatly perturbed, and the mental distress and anxiety in some instances appear to cause even more irritation than the bodily pain. Febrile movement when present accords with that observed in _monarticular_ sites, save only in the tendency to _relapses_. Sweating is not a common feature, as in _acute rheumatism_. Neither does acute _endocarditis_ occur in gout. On the other hand, as this acute polyarticular form may recur throughout years, it may in its later stages be complicated by _nephritis_. Furthermore, in its differentiation from acute rheumatism the more advanced age of the sufferer, always over thirty-five and more often nearer fifty or over, will be of help. The presence of an hereditary taint, the nature of the occupation and personal habits, and more pertinently the history of a classical attack in the great toe, may give a clue.