In the _choroid_ there may be true bone which forms a cup so extensive that it can be felt by the finger, or, again, there may be calcareous plaques. The _retina_ may undergo colloidal changes or be the site of carbonate of lime or of cholesterin. The _vitreous_ may sparkle with showers of cholesterin. The _lens_ may contain both tyrosine and cholesterin. The _aqueous_ shows similar crystals. In the _iris_ degenerative calcareous or osseous deposits are occasionally seen. The _cornea_ may be affected by hyaline degeneration with deposition of lime salts. The _conjunctiva_ may be calcareous. In all these cases the foreign particles, whether crystals or otherwise, are usually the retrogressive changes of senescence proclaiming that the forces which make for degeneration are more potent than those which make for regeneration. But _urates_ are not found _in_ the eye, even though the patient is gouty. On the other hand, both in gouty joints and in other similarly affected parts of the body we find a deposition of urate of soda. _Gouty Diathesis._—From the days of Sydenham—himself a martyr to gout—diathesis has been a name to conjure with, and an all-sufficient diagnosis. In the podagrous patient any intercurrent disorder, any inexplicable ache or pain, was ascribed to gout, and patient and doctor were alike satisfied. “Tempora mutantur,” but still we are prone to call morbid conditions gouty when they occur in gouty people. If we accept the theory that gout is due to an excess of uric acid in the blood, the view which I have expressed elsewhere[48] that gout does not cause iritis is directly challenged. For if it be granted that a sudden outpouring of so non-toxic an acid _causes_ an acute inflammation—for instance, in the synovia of the great toe—why should not our faith incline us to go further and find in this malevolent, though bland, acid a source of inflammation affecting the fibro-muscular meshwork of the iris? If, however, we adopt the infective theory, then the association of the uratic deposits no longer dominates our creed—we view them as mere clinkers and by-products erupted from the furnace. The infective theory of gout also lends plausibility to an association with iritis, for this latter is a disease of infective origin. For the intimate relationship of all forms of asthenic arthritis with iritis is of very frequent occurrence, but is practically never seen in the more sthenic arthritides: rheumatic fever, acute gout and traumatic arthritis. Nearly fifty years ago Jonathan Hutchinson drew up a “Report on the Forms of Eye Disease which occur in connection with Rheumatism and Gout.”[49] At the present day it is not easy to differentiate his 117 cases according to modern classification, but he includes gout, rheumatism, rheumatic arthritis, etc. The differential diagnosis between gout and rheumatism was simplified by the creation of a mule—“rheumatic gout”—and upon its back were packed the doubtful cases.