In 1842, being then twenty-two years old, and having saved a moderate sum of money, he formed a copartnership with Messrs. Case & Nelson, boat builders, of St. Louis, for the purpose of recovering steamboats and their cargoes which had been sunk or wrecked in the Mississippi. Accidents of this kind were then very common in those waters, and the business bade fair to be very profitable. The enterprise succeeded better than had been expected, and the operations of the wrecking company extended from Galena, Illinois, to the Balize, and into many of the tributaries of the great river. The parties interested in the scheme realized a handsome profit on their investments. Mr. Eads was the practical man of the concern, and worked hard to establish it upon a successful footing. In 1845 he sold out his interest in the company, and established a glass manufactory in St. Louis. This was the first enterprise of the kind ever attempted west of the Mississippi. Two years later, in 1847, he organized a new company for the purpose of recovering boats and cargoes lost in the Mississippi and its tributaries. This company started with a capital of fifteen hundred dollars. It was slow work at first, but a steady improvement was made every year, and in 1857, just ten years from the date of their organization, the property of the firm was valued at more than half a million of dollars. During the winter of 1856-'57, Mr. Eads laid before Congress a formal proposition to remove the obstructions from the western rivers and keep them open for a term of years, upon payment of a reasonable sum by the General Government. Had this proposition been accepted, the benefits thereby secured to all who were engaged in the navigation of those rivers would have been very great. A bill was reported in Congress authorizing the acceptance of Mr. Eads' offer, but was defeated through the influence of the Senators from Mississippi (Jefferson Davis) and Louisiana (J.P. Benjamin). In 1857, Mr. Eads was compelled, on account of ill-health, to retire from business. He had earned a handsome fortune by his industry and enterprise, and could well afford to rest for a short time, preparatory, as it afterward proved, to the most important part of his whole career.