In 1842, De Lesseps was transferred from Cairo to Spain, and was made consul at Barcelona. Spain was at this time much disturbed by factional quarrels and jealousies, partly due to disputed claims to the succession to the throne, and partly to the angry rivalries of political leaders, each eager to save the country by his particular nostrum. In the dynastic struggle, Queen Christina, made regent after the death of her husband, Ferdinand VII., had been exiled to France, and General Espartero, who at first had stood for her cause, now ruled as regent in her place. In 1843, the year after the arrival of De Lesseps, the city of Barcelona, which in common with many other places had refused to support Espartero, openly revolted, and was besieged and bombarded by his forces; and in the course of the siege, which brought great misery upon the inhabitants, De Lesseps did so many humane and generous acts at great personal risk, that he was rewarded by honors from the governments of several nations whose subjects had been protected by him in his official capacity. It was natural that after this proof of his abilities, De Lesseps should be advanced to a still higher position, and in the spring of 1848 he was made minister to Madrid. This place he held, however, only until February, 1849, for in May of that year he was sent to Rome to patch up a peace between the popular party and the French army of occupation. This proved an unfortunate venture. De Lesseps was recalled to France in disgrace, in June of the same year, for having shown too great a sympathy for the party of Mazzini, which aimed to establish a Roman Republic. It may be conjectured that the disappointment of De Lesseps at this abrupt ending of his diplomatic career was not very great. He had not been drawn to the profession by natural inclination, but had inherited it, so to speak, from his father, as another man might inherit the profession of law or medicine, or as the son of a mechanic might inherit his father's trade. His ambition and tastes both led him in a different direction; he would play a more active, a more striking part in the affairs of his time.