The method, however, met with much opposition, until, in the following year, thirty-three leading physicians and forty eminent surgeons of London signed an earnest expression of their confidence in the efficacy of the cow-pox. The royal family of England exerted themselves to encourage Jenner; the Duke of Clarence, the Duke of York, the king, the Prince of Wales, and the queen bestowed great attention upon Jenner. The incalculable utility of cow-pox was at last evinced; and observation and experience furnished evidence enough to satisfy the Baillies and Heberdens, the Monros and Gregorys of Britain, as well as the physicians of Europe, India, and America. The new practice now began to supersede the old plan pursued by the Small-pox Hospital, which had been founded for inoculation. The two systems were each pursued until 1808, when the hospital governors discontinued small-pox inoculation. A committee of Parliament was now appointed to consider the claims of Jenner upon the gratitude of his country. It was clearly proved that he had converted into scientific demonstration a tradition of the peasantry. Two parliamentary grants, of £10,000 and £20,000, were voted to him. In 1808 the National Vaccine Establishment was formed by Government, and placed under his direction. Honors were profusely showered upon him by various foreign princes, as well as by the principal learned bodies of Europe. Dr. Jenner passed the remainder of his years principally at Berkeley and at Cheltenham, continuing to the last, his inquiries on the great object of his life. He died at Berkeley, in February, 1823, at the green old age of seventy-four: his remains lie in the chancel of the parish church of Berkeley. A marble statue by Sievier has been erected to his memory in the nave of Gloucester Cathedral; and another statue of him has been placed in a public building at Cheltenham. Five medals have been struck in honor of Jenner: three by the German nation; one by the surgeons of the British navy; and the fifth by the London Medical Society. [Illustration: The First Vaccination--Dr. Jenner.]