The two systems which appealed most to enlightened pagans during the earlier Christian centuries were those of Pythagoras and Plato, which offered many points of likeness. By the union of these with certain Hebraic or Oriental elements, there arose the philosophical amalgam known as Neo-platonism. Plotinus is regarded as the founder of this system in the third century of our era. Through his attractive personality and the timeliness of his teachings, Plotinus rapidly gained a great following among the learned, especially philosophers, statesmen, physicians, and ladies of high social station. He passed many years in Rome, where a large number of noble ladies, including the Empress Salomina, were among his hearers. From Rome, Neo-platonism spread over the Empire; and in the beginning of the fourth century, we find the theosophist Iamblichus, who united the Neo-platonic philosophy with thaumaturgy, attracting to himself large numbers of highly cultured men and women, who still clung to paganism. Syria was the centre of this movement, which reached across Asia Minor and became popular even in Athens and Alexandria. Among the followers of Iamblichus in Asia was an excellent and learned woman, who became celebrated by her intense devotion to this philosophy. Sosipatra was the beautiful and noble-hearted wife of Eustathius, Prefect of Cappadocia. After the death of Eustathius, she became the wife of a kinsman, by name Philometor, and dedicated the rest of her life to the promotion of science and philosophy and to the education of her children, whom she herself instructed and of whom she made ardent and intelligent disciples of Neo-platonism. At Athens, where philosophical studies had for a long period declined, Platonism was revived by the Emperor Julian the Apostate, who appointed Plutarchus the first head of the New Academy. Plutarchus had a daughter, Asclepigenia by name, who had been initiated into all the mysteries of Neo-platonism and thaumaturgy, and who played a prominent role in the new school. It is related of her that after the death of her father she kept alive the knowledge of the great orgies and all the secret lore of thaumaturgy. In association with her brother Hierius, she became the head of the New Academy, and through her personality and her lectures she exercised a great influence over the philosophic youth of the day. Her daughter, Asclepigenia the Younger, was likewise a devoted Neo-platonist, and continued the traditions of the school. But the appearance of the two Asclepigenias in the history of philosophy cannot be regarded as of much importance, as the system of thaumaturgy which they advocated was scientifically worthless.