As to the initial form of the wave which the action of the left
ventricle produces in the arterial system, we get a hint from the
experiments of Grashey, v. Kries, and Marey, where the sudden
compression of a bag furnished the initial shock.[64] These changes of
pressure can be represented by a curve like that in Fig. 1.
So long as the contraction of the left ventricle lasts and the valves
are open, the action of the heart produces a certain pressure in the
aorta, but the influence of the intraventricular pressure is zero when
the valves are closed. The second phase of the curve Fig. 1, where the
pressure is zero, certainly gives the influence of the intraventricular
pressure during the diastole, because there is no communication between
the ventricle and the arterial system when the valves are closed. The
question is whether the rest of the curve can represent the changes of
the intraventricular pressure when the valves are open.
[Illustration: Fig. 1. Changes of pressure produced in a bag by sudden
compression.]
[Illustration: Fig 2. Decreasing amount of liquid in a tube when the
outflow is uniform.]
The first curves of intraventricular pressure were traced by Chauveau
and Marey. These experiments were made on a horse, and they have been
repeated since it was discovered that they can be performed also on
smaller animals. Besides Chauveau and Marey may be mentioned the names
of Fick, Huerthle, v. Frey, Rolleston, Bayliss and Starling. The curves
obtained by various observers belong to two types; one shows the so
called "plateau," the other does not. Recent experiments have proved
that this difference of results is due to a difference in methods. This
also is suggested by the fact that different curves have been obtained
from animals of the same species. Two methods have been applied lately
for testing these curves of intraventricular pressure. The first
was devised by Bayliss and Starling. It consisted chiefly in the
photographic registration of the movement of the liquid in a manometer
tube. The photographic registration is frictionless, and the mass of
the moving liquid was so small that vibrations by inertia were fairly
excluded for pressures which are not greater than the intraventricular
pressure.[65] The second method was used by Porter. The idea of this
method was to trace only a part of the curve, not the whole. The
writing lever, thus, has in the beginning of the tracing no inertia at
all, and the tracing may be overdrawn but is certainly correct in form
up to the next point of inflexion of the curve.[66] These tests and
the repeated experiments of Chauveau leave no doubt as to the existence
of the plateau.
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