The fourth factor of importance is the rate of outflow. We may introduce the following assumption as to the rate of outflow of the blood through the capillaries: The outflow through the capillaries is uniform in the short time of one heart-beat. The fact has been mentioned above that the quantity of outflowing blood must be equal to the quantity of incoming, for any stationary form of the pulse movement; this new hypothesis means that the velocity of the outflow is constant. One might think that this assumption is warranted by the law of Poiseuille that the amount of outflow through a horizontal capillary filled with liquid under constant pressure depends on the fourth power of the radius and on the difference of pressure at the two ends of the tube, and is inversely proportional to the constant of friction and to the length of the tube. This law has been proved mathematically and tested physically only for horizontal tubes and constant pressure. Neither of these suppositions holds for the capillaries of the arterial system. The connection between the hypothesis in question and Poiseuille's law is this. Let us suppose that an artery splits up in a great number of arterioles which go off in every direction. The amount of outflow is then a complicated function, because the law of Poiseuille does not hold for every direction of the capillaries; but it will be equal to the outflow through a tube of certain radius and certain direction in the same time. Our assumption says that the law of Poiseuille holds for this typical but imaginary tube. The essential point of this hypothesis is merely the supposition that the outflow of blood through the capillaries follows α law.[69]