The following description of how this terrible disease develops and affects the patient is taken from the Hankow (China) Medical Mission report: "Leprosy is common. It chiefly affects men who work in the field; we have met with it in brothers; it is occasionally met with in women. The age varies from ten to fifty years. Often the first symptom complained of is some localized anaesthesia--which is sometimes quite accidentally discovered--in the feet, hands, or face, which are the parts that are most commonly affected. The sensory nerves are first affected, and sensation as a rule absent partially or completely. The anaesthesia is followed by want of free use of affected parts; the circulation is also impaired in those parts; the hair on the eyebrows falls out. A peculiar punched-out-looking ulcer, with a very fetid discharge, is often met in the feet; sometimes, but not so often, in the hands. As the disease advances, which it does very slowly--it often apparently remains stationary for years--the face broadens, becomes square, glazed, irregular and nodular; nodules are also found in the mucous membrane of the lips and in the nerves; perspiration is absent; the natural expression of the face is completely changed; the patient looks old and sad. As the disease further advances, the toes and fingers drop off, and by and by part of the limb. The general health is never affected. Treatment is not very satisfactory; symptoms seem to be controlled for a time, but never cured." =Lockjaw.=--Professor Renzi, of Naples, records several cases of tetanus successfully treated by absolute rest. The method advocated is as follows: The patient's ears are closed with wax, after which he is placed in a perfectly dark room, far from any noise. He is made to understand that safety lies in perfect rest. The room is carpeted heavily in order to relieve the noise of stepping about. The nurse enters every quarter of an hour with a well-shaded lantern, using more the sense of touch than sight to find the bed. Liquid food (milk, eggs in beef tea, and water) is carefully given, so that mastication is not necessary. Constipation is not interfered with. Mild doses of belladonna or secale are given to relieve pain. This treatment does not shorten the disease, but under it the paroxysms grow milder, and finally cease. Numerous physicians attest to the value of this treatment. =Marriage.=--The _Medical Record_ says the unpopularity of marriage in England continues unabated, and last year was the first in recent times in which, while the price of wheat fell, the marriage rate remained stationary. It is now 14.2 per 1,000. The decline in the popularity of matrimony is greatest with those who have already had some experience of wedded life. Between 1876 and 1888 the marriage rate fell 12 per cent for bachelors and spinsters, 27 per cent for widowers, 31 per cent for widows.