_Cocaine_ is the alkaloid of the coca plant of South American origin. It is generally employed in the form of muriate of cocaine and principally used as a local anaesthetic. It should only be used under the direction of a physician. It may occasion dangerous effects even in doses usually deemed safe. When it has been taken internally, the proper antidote is a powerful emetic followed by stimulants--such as liquor and spirits of ammonia--administered internally. When it has been used to a dangerous extent externally, give whisky or brandy and ammonia. _Laudanum, Opium, Paregoric, Morphia, Belladonna, Hyoscyamus, Stramonium, and Conium._--An emetic of mustard and water, twenty grains of sulphate of zinc (white vitriol), or thirty grains of powdered ipecac, should be given. Strong coffee, brandy, or whisky should then be administered in large quantities, and the patient walked around the room. Slapping, pinching, dashing cold water in the face, and even whipping, may be necessary to keep the patient awake. _Strychnine (Nux Vomica)._--Give an emetic of a solution of sulphate of zinc (white vitriol), or a strong infusion of tobacco; or inject into the bowels bromide of potassium, thirty grains, and the extract of coca, one-half ounce. During the spasms, the patient should breathe chloroform or ether from a saturated cloth held to the nose and mouth. _Toadstools (False Mushrooms) and other poisonous plants and seeds, such as are liable to be picked up and eaten by children._--Empty the stomach at once by an emetic you have at hand. Coffee poisoning occurs mostly with well-to-do people--those who are overfed. Tea poisoning comes to hard-working, half-starved women. The symptoms of coffee poisoning are want of appetite, sleeplessness, and nervous tremblings, with various indications of indigestion and torpor of liver. Tea poisoning requires rest and nourishment; but the victim of coffee excess usually needs to unload his system by exercise on a low diet. _Antipyrine._--Dr. T. E. Smith, of Cincinnati, had his whole right side paralyzed by a ten-grain dose of antipyrine. The dose is an ordinary one. This powerful drug is much resorted to by grippe victims.