However that may be, it was not for Clement VII. to deride England's conduct. The keen-sighted Pace had remarked in 1521 that, in the event of Charles's victory, the Pope would have to look to his affairs in time.[425] The Emperor's triumph was, indeed, as fatal to the Papacy as it was to Wolsey. Yet Clement VII., on whom the full force of the blow was to fall, had, as Cardinal de Medici, been one of the chief promoters of the war. In August, 1521, the Venetian, Contarini, (p. 153) reports Charles as saying that Leo rejected both the peace and the truce speciously urged by Wolsey, and adds, on his own account, that he believes it the truth.[426] In 1522 Francis asserted that Cardinal de Medici "was the cause of all this war";[427] and in 1527 Clement VII. sought to curry favour with Charles by declaring that as Cardinal de Medici he had in 1521 caused Leo X. to side against France.[428] In 1525 Charles declared that he had been mainly induced to enter on the war by the persuasions of Leo,[429] over whom his cousin, the Cardinal, then wielded supreme influence. So complete was his sway over Leo, that, on Leo's death, a cardinal in the conclave remarked that they wanted a new Pope, not one who had already been Pope for years; and the gibe turned the scale against the future Clement VII. Medici both, Leo and the Cardinal regarded the Papacy mainly as a means for family aggrandisement. In 1518 Leo had fulminated against Francis Maria della Rovere, Duke of Urbino, as "the son of iniquity and child of perdition,"[430] because he desired to bestow the duchy on his nephew Lorenzo. In the family interest he was withholding Modena and Reggio from Alfonso d'Este, and casting envious eyes on Ferrara. In March, 1521, the French marched to seize some Milanese exiles, who were harboured at Reggio.[431] Leo took the opportunity to form an alliance with Charles for the expulsion of Francis from Italy. It was signed at Worms on the 8th of May, the day on which Luther was outlawed;[432] and a war broke out in Italy, the effects of which (p. 154) were little foreseen by its principal authors. A veritable Nemesis attended this policy conceived in perfidy and greed. The battle of Pavia made Charles more nearly dictator of Europe than any ruler has since been, except Napoleon Bonaparte. It led to the sack of Rome and the imprisonment of Clement VII. by Charles's troops. The dependence of the Pope on the Emperor made it impossible for Clement to grant Henry's petition for divorce, and his failure to obtain the divorce precipitated Wolsey's fall. [Footnote 425: _L. and P._, iii., 1370.] [Footnote 426: _Ven. Cal._, iii., 312.] [Footnote 427: _L. and P._, iii., 1947.] [Footnote 428: _Sp. Cal._, iii., pp. 510-11.] [Footnote 429: _Ibid._, ii., p. 717.] [Footnote 430: _L. and P._, ii., 3617.]