The plant is given powdered, or as an infusion, or made into a tincture (H.) with spirit of wine. From ten to sixty grains of the powder may be taken for a dose, or a decoction may be made by boiling two ounces of the bruised plant with half-a-pint of water, and giving one tablespoonful for a dose several times in the day; or from five to ten drops of the tincture (which is prepared almost exclusively by the homoeopathic chemists) are a dose, with one or two tablespoonfuls of cold water. Sir John Colebatch published in 1720 a pamphlet, on _The Treatment of Epilepsy by Mistletoe_, regarding it, and with much justice, as a specific. He procured the parasite from the lime trees at Hampton Court. The powdered leaves were ordered to be given (in black cherry water), as much of these as will lie on a sixpence every morning. Sir John says, "This beautiful plant must have been designed by the Almighty for further and more noble purposes than barely to feed thrushes, or to be hung up superstitiously in houses to drive away evil spirits." His treatise was entitled, _A Dissertation concerning the Misseltoe--A most wonderful Specifick Remedy for the Cure of Convulsive Distempers_. The physiological effect of the [347] plant is that of lessening, and temporarily benumbing such nervous action as is reflected to distant organs of the body from some central organ which is the actual seat of trouble. In this way the spasms of epilepsy and of other convulsive distempers, are allayed. Large doses of the plant, or of its berries, would, on the contrary, aggravate these convulsive disorders. In a French "_Recueil de Remedes domestiques_," 1682, _Avec privilege du Roy_, we read, de l'epilepsie: "Il est certain que contre ce deplorable mal le veritable Guy de Chene (Mistletoe) est un remede excellent, curatif, preservatif, et qui soulage beaucoup dans l'accident. Il le faut secher au four apres qu'on aura tire le pain: le mettre en poudre fort subtile; passer cette poudre par un tamis de foye, et la conserver pour le besoin. Il faut prendre les poids dun ecu d'or de cette poudre chaque matin dans vin blanc tous les trois derniers jours de la lune vieille. Il est encore bon que la personne affligee de ce mal porte toujours un morceau de Guy de Chene pendu a son col; mais ce morceau doit etre toujours frais, et sans avoir ete mis au four." The active part of the plant is its resin (_viscin_), which is yielded to spirit of wine in making a tincture. This is prepared (H.) with proof spirit from the leaves and ripe berries of our Mistletoe in equal quantities, but it is difficult of manufacture owing to the viscidity of the sap. A special process is employed of passing the material twice through a sausage machine, and then mixing the mass with powdered glass before its percolation with the spirit. A trituration made from the leaves, berries, and tender twigs, is given for epilepsy, in doses of twenty grains, twice or three times a day.