Reinbach has found them in a case of lymphosarcoma with metastases in
the bone-marrow. A. Lazarus observed their transitory occurrence in
moderate number in a severe posthaemorrhagic anaemia. M. Beck observed
them in the blood of a patient with severe mercury poisoning. They are
also frequently found in children's diseases, especially in _anaemia
pseudoleukaemica infantum_. K. Elze established their presence in a boy
of 15 months, suffering from a slowly progressing tuberculosis of the
lymphatic glands.
The appearance of myelocytes in infectious diseases is particularly
interesting. Rieder had previously demonstrated that myelocytes may be
present in acute inflammatory leucocytoses; and recently a thorough
work by C. S. Engel has appeared upon the occurrence of myelocytes in
diphtheria. Engel discovered the interesting fact, that myelocytes are
often to be found in children suffering from diphtheria, and further
made the important observation that a high percentage of myelocytes
(3.6-16.4% of the white elements) only occurs in severe cases, and
points to an unfavourable prognosis. Myelocytes are also present in mild
cases, though not constantly and in much smaller number. Tuerk has
recently undertaken a very exact and thorough analysis of their
occurrence in infectious diseases, in the course of which he accurately
tabulated the white corpuscles in a large number of cases. The results
he obtained in pneumonia are especially characteristic, for he found at
the commencement of the disease that myelocytes are not seen at all or
only very scantily: and it is only at the time of the crisis, or
directly afterwards, that they become specially numerous. In isolated
cases the increase at this time was very considerable; and in one case
amounted almost to 12% of all neutrophil cells.
2. Mononuclear eosinophil cells ("=eosinophil myelocytes="). H. F. Mueller
was the first to point out their importance. They constitute the
eosinophil analogue of the previous group, and are much larger than the
polynuclear eosinophils; medium and small sized examples are often found
in leukaemia. Eosinophil myelocytes are almost constantly present in
myelogenous leukaemia and in anaemia pseudolymphatica infantum. Apart from
these two diseases they are very rarely found; Mendel saw them for
example in a case of myxoedema, Tuerk quite exceptionally in some
infectious diseases.
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