3. =Small neutrophil pseudolymphocytes.= They are about as large as the
small lymphocytes, possess a rounded deeply stained nucleus, and a small
shell of protoplasm studded with a neutrophil granulation. The
relatively deep stain of the nucleus and the small share of the
protoplasm in the total cell body prevent confusion with the small forms
of myelocytes, which never reach such small dimensions. The neutrophil
pseudolymphocytes are exceedingly infrequent, and represent products of
division of the polynuclear cells; they were first described by Ehrlich
in a case of hemorrhagic small-pox. The process of division goes on in
the blood in such a manner that the nuclear rod first divides into two
to four single nuclei, and then the whole cell splits up into as many
fragments. These cells occur also in fresh pleuritic exudations. After a
time the nucleus of these cells becomes free, and the little masses of
protoplasm thus cut off are taken up mostly by the spleen substance. The
free nucleus likewise shares in the destruction. It is of the greatest
importance that these cells, which up to the present have not elsewhere
been described, should receive more attention. They must be of
significance, in particular for the question of transitory
hyperleucocytosis, which is by some referred to a destruction, by others
to an altered localisation of the white blood corpuscles.
4. "=Stimulation forms=" were first described by Tuerk, and are mononuclear
non-granulated cells. They possess a protoplasm staining with various
degrees of intensity, but in any case giving with triacid solution an
extraordinarily deep dark-brown, and further a round simple nucleus
often eccentrically situated, stained a moderately deep bluish-green,
with however a distinct chromatin network. The smallest forms stand
between the lymphocytes and the large mononuclear leucocytes, but
approach the first named as a whole in their size and general
appearance. According to Tuerk's investigations, these cells often occur
simultaneously with, and under the same conditions as the myelocytes.
Their importance cannot at present be accurately gauged. Possibly they
form an early stage of development of the nucleated red blood
corpuscles, as the deeply staining and homogeneous protoplasm seems to
indicate.
With the description of these abnormal forms of white corpuscles all
occurring forms are by no means exhausted. We are here excepting
completely the variations in size which particularly affect the
polynuclear and eosinophil cells, and which lead to dwarf and giant
forms of them. For however considerable the difference in size, these
cells always possess characteristics sufficient for an exact diagnosis.
But besides these, isolated cells of an especially large kind are found
particularly in leukaemic blood, and concerning their importance and
relationship we are up to the present in the dark.
FOOTNOTES:
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