The project for interoceanic communication by way of the isthmus of Panamá was first mooted more than three hundred and fifty years ago, and to Charles V. probably belongs the merit of its suggestion. The plan first proposed was to unite the Rio Grande with the Chagre, which except in seasons of drought was navigable for vessels of light draught as far as the present town of Cruces, and so make the connection on the Pacific side near the modern city of Panamá. Andagoya, who has already been mentioned as the one who in 1522 conducted an expedition to Birú, was directed to make a survey and to furnish estimates of the probable cost. His report was unfavorable; for in a despatch addressed to the emperor, about 1534, he expresses his belief that there was no monarch in all Europe rich enough to furnish the means to carry out such an enterprise.[XV‑2] In the same despatch Andagoya also reports adversely on a question which had been for several years under discussion—that of moving to another site the population of Panamá. In a letter addressed to Francisco Pizarro in 1531, Antonio de la Gama declares his intention of making such a change; for ever since the city had been founded by Pedrarias, complaints had been made of its unhealthy climate.[XV‑3] A royal cédula was afterward issued ordering that the citizens should meet and discuss the question, and Andagoya states that the matter was decided in the negative; for, he tells us: "There is no other port in all the South Sea where vessels could anchor alongside the streets." Moreover he affirms that "God himself had selected the site." The chronicler Benzoni, who travelled in Darien between 1541 and 1556, mentions that the road from Panamá[XV‑4] to Nombre de Dios was about fifty miles in length, and that during the first day's journey it was tolerably smooth, but the remainder of the route lay over rugged and difficult ground, through forest and through streams sometimes almost impassable during the rainy season.[XV‑5] Merchants doing business at Nombre de Dios usually resided at Panamá. At the time of Benzoni's visit to the former town, about the year 1541, it contained but fifteen or twenty wholesale merchants, the remainder of the population being principally small tradesmen, innkeepers, and sailors. The trade of Nombre de Dios was extremely fluctuating. Fourteen or fifteen Spanish vessels of various sizes, the largest being about three hundred and sixty tons burden, arrived there annually, with miscellaneous cargoes, but laden principally with wine, flour, biscuit, oil, cloth, silk, and household merchandise. The prices obtained for goods depended altogether upon the supply. When the market was overstocked, prices frequently ruled lower than first cost in Spain, and cargoes were sometimes forfeited by the consignee as not worth the freight. On the other hand, when an article was scarce, an enormous price could be obtained for it, sometimes its weight in gold.