[Sidenote: The intellectual ruin of ecclesiasticism.] Such is the history of the dispute respecting the position of the earth in the universe. Not without reason, therefore, have I assigned the pontificate of Nicolas V. as the true close of the intellectual dominion of the Church. From that time the sceptre had passed into another hand. In all directions Nature was investigated, in all directions new methods of examination were yielding unexpected and beautiful results. On the ruins of its ivy-grown cathedrals, Ecclesiasticism, surprised and blinded by the breaking day, sat solemnly blinking at the light and life about it, absorbed in the recollection of the night that had passed, dreaming of new phantoms and delusions in its wished-for return, and vindictively striking its talons at any derisive assailant who incautiously approached too near. I have not space to describe the scientific activity displayed in all directions; to do it justice would demand volumes. Mathematics, physics, chemistry, anatomy, medicine, and all the many branches of human knowledge received an impulse. [Sidenote: Wonderful development of scientific activity.] Simultaneously with the great events I have been relating, every one of these branches was advancing. Vieta made the capital improvement of using letters as general symbols in algebra, and applied that science to geometry. Tycho, emulating Hipparchus of old, made a new catalogue of the stars; he determined that comets are beyond the moon, and that they cut the crystalline firmament of theology in all directions. Gilbert wrote his admirable book on the magnet; Gesner led the way to zoology, taking it up at the point to which the Saracens had continued Aristotle, by the publication of his work on the history of animals; Belon at the same time, 1540, was occupied with fishes and birds. Fallopius and Eustachius, Arantius and Varolius, were immortalizing themselves by their dissections: the former reminding us of the times of Ptolemy Philadelphus, when he naïvely confesses "the Duke of Tuscany was obliging enough to send living criminals to us, whom we killed and then dissected." Piccolomini laid the foundations of general anatomy by his description of cellular tissue. Coiter created pathological anatomy, Prosper Alpinus diagnosis, Plater the classification of disease, and Ambrose Paré modern surgery. Such were the occupations and prospect of science at the close of the sixteenth century.