Good Friday, in the year 1016, an earthquake destroyed many of the houses in Rome. Pope Benedict VIII., having learned that at the time of its occurrence the Jews were worshipping in their synagogue, and attributing the catastrophe to their influence, caused a great number to be massacred. At all times they were exposed to the contumely of adults and the petty persecutions of children. The isolated quarter in every community, to which their residence was restricted, and separated from the dwellings of orthodox Christians to prevent contamination, is to-day, in nearly all the cities of Europe, still known by its once distinctive name; although, in most instances, its Jewish population has disappeared. It was also a common pastime of the mob to stone the houses of the Jews, and, as the latter were not permitted to defend themselves, all large towns resounded with tumult and disorder during the celebration of the most sacred festival of Christendom. Upon every occasion, these unfortunates were pursued and baited like wild animals; always with the tacit connivance, often with the open encouragement, of the authorities. Their intimate relations with the countries of the East offered substantial grounds for the belief that they introduced leprosy into France, Spain, and England,--a disease whose general dissemination has ordinarily been credited to the Crusades, but whose existence in France as early as the sixth century must be attributed to some anterior agency. The undoubted Oriental origin of this malady pointed strongly to the itinerant Jewish merchants as responsible for its appearance in Western Europe; while its loathsome and incurable character tended to increase the popular odium with which those suspected of infecting a portion of the human race hitherto exempt from this affliction were universally regarded.