The manner of its first coming to London proves this also, viz., by goods brought over from Holland, and brought thither from the Levant; the first breaking of it out in a house in Longacre where those goods were carried and first opened; its spreading from that house to other houses by the visible unwary conversing with those who were sick, and the infecting the parish officers who were employed about persons dead; and the like. These are known authorities for this great foundation point, that it went on and proceeded from person to person, and from house to house, and no otherwise. In the first house that was infected, there died four persons. A neighbor, hearing the mistress of the first house was sick, went to visit her, and went home and gave the distemper to her family, and died, and all her household. A minister called to pray with the first sick person in the second house was said to sicken immediately, and die, with several more in his house. Then the physicians began to consider, for they did not at first dream of a general contagion; but the physicians being sent to inspect the bodies, they assured the people that it was neither more or less than the plague, with all its terrifying particulars, and that it threatened an universal infection; so many people having already conversed with the sick or distempered, and having, as might be supposed, received infection from them, that it would be impossible to put a stop to it. Here the opinion of the physicians agreed with my observation afterwards, namely, that the danger was spreading insensibly: for the sick could infect none but those that came within reach of the sick person; but that one man, who may have really received the infection, and knows it not, but goes abroad and about as a sound person, may give the plague to a thousand people, and they to greater numbers in proportion, and neither the person giving the infection, nor the persons receiving it, know anything of it, and perhaps not feel the effects of it for several days after. For example:-- Many persons, in the time of this visitation, never perceived that they were infected till they found, to their unspeakable surprise, the tokens come out upon them, after which they seldom lived six hours; for those spots they called the tokens were really gangrene spots, or mortified flesh, in small knobs as broad as a little silver penny, and hard as a piece of callus[264] or horn; so that when the disease was come up to that length, there was nothing could follow but certain death. And yet, as I said, they knew nothing of their being infected, nor found themselves so much as out of order, till those mortal marks were upon them. But everybody must allow that they were infected in a high degree before, and must have been so some time; and consequently their breath, their sweat, their very clothes, were contagious for many days before.