Another candidate was Christine, duchess of Lorraine, the king's cousin. The large estates of her house lay in the neighborhood of the Netherlands. She had shown her talent for political affairs by the part she had taken in effecting the arrangements of Cateau-Cambresis. The prince of Orange, lately become a widower, was desirous, it was said, of marrying her daughter. Neither did this prove a recommendation with Philip, who was by no means anxious to raise the house of Orange higher in the scale, still less to intrust it with the destinies of the Netherlands. In a word, the monarch had no mind to confide the regency of the country to any one of its powerful nobles.[406] The individual on whom the king at length decided to bestow this mark of his confidence was his half-sister, Margaret, duchess of Parma. She was the natural daughter of Charles the Fifth, born about four years before his marriage with Isabella of Portugal. Margaret's mother, Margaret Vander Gheenst, belonged to a noble Flemish house. Her parents both died during her infancy. The little orphan was received into the family of Count Hoogstraten, who, with his wife, reared her with the same tenderness as they did their own offspring. At the age of seventeen she was unfortunate enough to attract the eye of Charles the Fifth, who, then in his twenty-third year, was captivated by the charms of the Flemish maiden. Margaret's virtue was not proof against the seductions of her royal suitor; and the victim of love--or of vanity--became the mother of a child, who received her own name of Margaret. [Sidenote: MARGARET OF PARMA REGENT.] The emperor's aunt, then regent of the Netherlands, took charge of the infant; and on the death of that princess, she was taken into the family of the emperor's sister, Mary, queen of Hungary, who succeeded in the regency. Margaret's birth did not long remain a secret; and she received an education suited to the high station she was to occupy in life. When only twelve years of age, the emperor gave her in marriage to Alexander de'Medici, grand duke of Tuscany, some fifteen years older than herself. The ill-fated connection did not subsist long, as, before twelve months had elapsed, it was terminated by the violent death of her husband.