The great body of the travel to California is at present by way of the Isthmus of Panama; but those who intend to settle permanently in the State, and who will increase the real population of it, take the overland route from Independence, Missouri. The shortest and best route for commercial purposes will soon be opened across Nicaragua. This will have many advantages over the old Isthmus route, but will not cause that one to be abandoned altogether. Chagres has become somewhat Americanized, and so have Gorgona, Cruces, and Panama. Travel has been somewhat facilitated by the addition of American boats on the Chagres River, and the provision of the mountain mules for the rough road to Panama, in sufficient number to lower the price of travel and decrease the delay. The facilities of intercourse between California and the States east of the Rocky Mountains will tend to cement her to the Union by all the ties of trade and mutual interest. The people of that State, being at so great a distance from the rest of the States, would seem to be alien to them in interest, and, therefore, that an independent government would contribute most to their prosperity. But mechanical influences--the telegraph--the railroad and the steam vessel--annihilate distance, and will be the means of attaching the Californians to the confederacy. In her union with the other States, there is her strength. She will add much to their wealth and power, but her free institutions--entirely American, require the support of the confederacy which produced them--at least, until the State has reached her maturity. What will be the future California is a question which admits of a ready answer. If she retains her present boundaries, with her extensive sea coast, and her progress bears any proportion to that since the conquest, in fifty years--it is a warranted conclusion--the State will surpass any of those upon the Atlantic coast. For, what State has such united commercial facilities and vast resources? Where are such internal wealth and such splendid harbors to be found united? It is probable, however, that the State may be divided, after the population has reached a sufficient number. It is the opinion of some of the members of the present Congress, that there is too much sea coast for one State to possess, and that has been made an objection to her admission into the Union, with her present boundaries. But it is of little weight at this time. After the State has existed a few years, the utility of such a division as is proposed will be manifest or disproved. In the mean time, let California be admitted into the Union as her people have created her, and then she will have every thing necessary for her to go on in the fulfilment of a glorious destiny.