Hormones and Heredity: A Discussion of the Evolution of Adaptations and the Evolution of SpeciesCunningham, J. T. (Joseph Thomas)
Science
Hormones and Heredity: A Discussion of the Evolution of Adaptations and the Evolution of Species
Cunningham, J. T. (Joseph Thomas)
Endocrinology; Heredity; Hormones; Mendel's law
Davenport repeated Guthrie's experiments on different fowls, grafting the
ovary from a cinnamon-coloured hen into a white hen, and mating her with a
cinnamon-coloured cock. The chicks were exactly similar to those obtained
from crossing such a cock with a normal white hen, and Davenport concludes
that the engrafted ovary was not functional but had degenerated. It is
known to be almost if not quite impossible to remove the ovary completely
from a hen, owing to its close attachment over the great post-caval vein.
At the same time it is difficult to see how Guthrie could have obtained
black and spotted chicks from a white hen mated with, a white cock if the
grafted ovary from a black hen had not been functional. One point which
Guthrie does not mention, and of which apparently he was not aware, is
that the white of the White Leghorn is dominant to colour, the
heterozygotes not being pure white but white with spots. Thus when he
mated a black cock with a white hen with grafted ovary and obtained
spotted chicks, this would have been the result if the original white
ovary was functional. None of his results prove conclusively the influence
of the soma of the hen into which ovaries were grafted, but would all be
explained if some eggs were derived from the part of the original ovary
not removed in the operation, and others from the grafted ovary.
The grafting of ovaries in Mammals has often been tried, but very rarely
with success. The introduced ovary usually dies and is absorbed. C. Foa
[Footnote: _Arch. Ital. de Bid._ (1901), Tome xxxv.] states that he made
bilateral grafts of ovaries from newborn rabbits into adult rabbits, and
two months after the operation one of the operated females was fecundated
and produced five normal young. In other cases he placed ovaries from
new-born young in positions far from the normal position, such as the
space between the uterus and bladder, and in one case the female so
treated became pregnant, and when killed had a single embryo in one uterus
and no trace of the original ovaries in the normal position. But Foa was
not investigating the influence of somatic characters on ova in the
grafted ovaries, and does not even mention the characters or breed of the
rabbits he used or of the young which were produced from the grafted
ovaries. Castle [Footnote: W. E, Castle and J. C. Phillips, _On Germinal
Transplantation in Vertebrates_, Pub. Carnegie Institution in Washington
(1911), No. 144.] carried out seventy-four transplantations of ovaries
principally in guinea-pigs. Out of all these only one grafted female
produced young. In this case the ovaries of two different black
guinea-pigs about one month old were grafted into an albino female about
five months old. After recovery the grafted female was kept with an albino
male. She produced six young in three pregnancies, first two, then one,
and lastly died with three foetus in the uteri. All these were black, with
some red hairs among the black.
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