Sir--In compliance with the request you did me the honor to make last Winter, while in Washington, I herewith transmit to you the synopsis of a bill which, if it could be adopted, would, according to my experience and observation, prove highly conducive to the best interests of the United States, generally, to Oregon, where I have resided for more than seven years as a missionary, and to the Indian tribes that inhabit the immediate country. The Government will now doubtless for the first time be apprised through you, or by means of this communication, of the immense immigration of families to Oregon which has taken place this year. I have, since our interview, been instrumental in piloting across the route described in the accompanying bill, and which is the only eligible wagon road, no less than three hundred families, consisting of one thousand persons of both sexes, with their wagons, amounting to one hundred and twenty, six hundred and ninety-four oxen, and seven hundred and seventy-three loose cattle. The emigrants are from different States, but principally from Missouri, Arkansas, Illinois and New York. The majority of them are farmers, lured by the prospect of bounty in lands, by the reported fertility of the soil, and by the desire to be first among those who are planting our institutions on the Pacific Coast. Among them are artisans of every trade, comprising, with farmers, the very best material for a new colony. As pioneers, these people have undergone incredible hardships, and having now safely passed the Blue Mountain Range with their wagons and effects, have established a durable road from Missouri to Oregon, which will serve to mark permanently the route for larger numbers, each succeeding year, while they have practically demonstrated that wagons drawn by horses or oxen can cross the Rocky Mountains to the Columbia River, contrary to all the sinister assertions of all those who pretended it to be impossible.