The act of breathing occurs in man about seventeen times per minute. While the inspired air is in contact with the interior of the lungs, it undergoes important alterations. It comes into contact with the five or six millions air-vesicles which form the minute dilated terminations of the windpipe, and have an aggregate area of ten to twenty square feet. Each of the air-vesicles has extremely thin walls; and outside these delicate walls lie capillary blood-vessels, full of impure blood. An active interchange now occurs between the air and the gases dissolved in the blood. Oxygen passes through the intervening membrane into the blood, while carbonic acid and other impurities of the blood pass into the air-vesicle. The consequence of this is that the impure dark-coloured blood becomes bright scarlet and pure. This purification is not confined to any one portion of the blood; for the heart contracting 60 or 70 times per minute, pours successive portions of blood into the capillaries surrounding the air-vesicles; while at the same time, pure air is brought into the air-vesicles seventeen times per minute, and so the interchange is constantly kept up. In view of the incessant character of respiration and circulation, it is clear that all the blood will be purified if the external air is pure; and that if there is any detrimental matter in the air, it probably will come into contact with the blood in the lungs. The amount of air taken in with each inspiration is about thirty cubic inches. This is called the _tidal air_, as it is constantly ebbing and flowing from and to the lungs. By means of a very forced inspiration, about 100 cubic inches of additional air can be inspired; and similarly after an ordinary inspiration, one can expire forcibly an additional 100 cubic inches, though there will still be left in the lungs another 100 cubic inches of air. Thus:— _Tidal air_ 30 cub. in. _Complemental air_ 100 „ _Supplemental air_ 100 „ _Residual air_ 100 „ ———— _Total capacity of lungs_ 330 „ Corresponding to the respiratory changes in the lungs, there are changes in the tissues throughout the body. The pure and oxygenated blood leaving the lungs, is carried to all parts of the system. Oxidation and allied processes are actively carried on, the result of which is the formation of urea, carbonic acid, and smaller quantities of other effete matters. These are then carried by the blood to the excretory organs, urea being chiefly eliminated by the kidneys, and carbonic acid by the lungs. =Examination of Expired Air= shows that—1. It is _heated_; in its passage through the nose and deeper respiratory passages it has acquired a temperature approaching that of the blood.