The prolonged breathing of air, foul from the products of respiration, is perhaps more common in workshops and schools than in private houses; but in both, a faint smell is commonly perceptible on entering from the open air, indicating imperfect ventilation and accumulation of organic putrescible matter. The preceding remarks are left as in the last edition. It must be noted, however, that recent research attaches more importance to the particulate matter (dust) in the atmosphere than to the amount of gaseous impurity, though the latter remains a convenient index of impurity. Experiments made by Drs. Haldane and L. Smith on themselves negative the older conclusion that a special organic poison exists in expired air. They were able without any appreciable effect on themselves to breathe air which was vitiated to such an extent as to completely prevent a match from burning; and they conclude that excess of carbonic acid and deficiency of oxygen are the sole cause of danger from breathing air highly vitiated by respiration. This conclusion may be accepted under the conditions of these experiments. Under ordinary conditions, however, the evil effects produced by breathing the air of crowded rooms, are due not only to the excess of carbonic acid and deficiency of oxygen, but also to the dust which is usually associated with them. This dust, which may be derived from handkerchiefs of patients suffering from influenza, consumption, sore throat, &c., or from other sources, is apt to be inhaled by the persons occupying such rooms. The =tendency to catarrhs= is greatly increased by living in a vitiated atmosphere. In the causation of “colds” two elements are concerned, the infective agent, and the condition of the patients. “Colds” are caused primarily by infection from previous patients. The nasal discharge of a “cold in the head” contains the contagium. This is dried on handkerchiefs, and is subsequently scattered as dust, and thus conveyed to others. Ordinarily there is considerable resisting power against such catarrhs. When, however, the general vitality or the local vitality of the mucous membrane of the nose, throat, and lungs is impaired by the breathing of impure air or by sitting in wet clothes after exposure to wet and cold, a catarrh is produced. The close connection of =phthisis= (consumption) with overcrowding and the breathing of a vitiated atmosphere will be discussed hereafter (page 313). The polluted air acts in producing consumption by depressing vital functions, and diminishing the powers of resistance against the actual contagium of the disease, which is inhaled as dust, produced by the drying of the expectoration of consumptive patients. The germs of infectious diseases are propagated very rapidly in an impure atmosphere; and typhus fever occurs almost solely in conditions of overcrowding.