The =Effect on the Temperature= is to lower it; but unless the dose is excessive, this effect is hardly appreciable. The resistance to excessive cold is diminished by even moderate doses of alcohol, still more by large doses. In the Arctic regions, this has been abundantly proved. This effect is produced, notwithstanding the fact that alcohol becomes oxidised in the system. The dilatation of the surface blood vessels leads to a greater loss of heat than that produced by the oxidation of the alcohol. EFFECTS OF IMMODERATE DOSES OF ALCOHOL ON THE SYSTEM.—Bearing in mind the definition given of a moderate dose, one is bound to admit that a large number of individuals exceed this amount daily, apparently without any very serious results. The system becomes habituated to large doses, and if the occupation is a laborious one, they may in part be oxidised in the system. Such, however, are exceptional cases. In the majority of cases evil results are by no means confined to those who indulge in very large quantities of alcohol at varying intervals. In fact these very often escape comparatively free, while others who never take a quantity sufficient to incapacitate them for their work, are sowing the seeds of chronic and oft incurable disease. The labourer who has a drinking bout at intervals is thoroughly nauseated; and the condition of liver and stomach induced, enforces abstinence on him for a time sufficient to bring his organs back to a normal condition; while the city merchant who indulges more moderately, but whose organs are almost continuously impregnated with alcohol, becomes gouty and prematurely old. The =Stomach= may become acutely inflamed, when a large dose of alcohol is taken. The chronic irritation of alcohol, especially when taken apart from meals, causes atrophy of the walls of the stomach, and a change analogous to that in the liver. The =Liver=, when alcohol is daily taken immoderately, becomes seriously diseased. In some cases it becomes large and fatty; in others the chronic irritation excites an overgrowth of fibrous tissue between the lobules of the liver, which, gradually shrinking, squeezes the liver cells and causes them to atrophy, at the same time obstructing the small branches of the portal vein in the substance of the liver. The consequence of this obstruction to the flow of blood through the liver is that all the organs from which the portal vein brings blood become overloaded with blood, and vomiting of blood and dropsy of the abdomen occur at a later period. The =Lungs= are irritated to a less extent by alcohol in large doses. The tendency to chronic bronchitis is increased, followed by emphysema, and sometimes an overgrowth of fibrous tissue (cirrhosis) like that in the liver occurs. The =Heart and Blood-vessels= tend to become diseased, owing largely to the gouty condition of system developed.