_Chambers's Journal_.] but if followed up for any length of time, the powerful habit may be formed ere one is aware. Then comes the opium eater's grave, or the opium eater's struggle for life! 4. CHLORAL HYDRATE. CHLORAL HYDRATE is a drug frequently used to cause sleep. It leaves behind no headache or lassitude, as is often the case with morphine. It is, however, a treacherous remedy. It is cumulative in its effects, _i. e._, even a small and harmless dose, persisted in for a long period, may produce a gradual accumulation of evil results that in the end will prove fatal. THE PHYSIOLOGICAL EFFECT of its prolonged use is very marked. The appetite becomes capricious. The secretions are unnatural. Nausea and flatulency often ensue. Then the nervous system is involved. The heart is affected. Sleep, instead of responding to the drug, as at first, is broken and disturbed. The eyesight fails. The circulation is enfeebled, and the pulse becomes weak, rapid, and irregular. There is a tendency to fainting and to difficult respiration. Sometimes the impoverished blood induces a disease resembling scurvy, the ends of the fingers ulcerate, and the face is disfigured by blotches. An excessive dose may result in death. Prolonged habitual use of chloral hydrate tends to debase the mind and morals of the subject in the same manner as indulgence in alcohol, ether, or chloroform. 5. CHLOROFORM. CHLOROFORM is an artificial product generally obtained, by distillation, from a mixture of chloride of lime, water, and alcohol. It was discovered in 1831 by Samuel Guthrie, of Sackett's Harbor, New York. It is a colorless, transparent volatile liquid, with a strong ethereal odor. PHYSIOLOGICAL EFFECT.--Chloroform is a powerful anæsthetic, which, when inhaled, causes a temporary paralysis of the nervous system, and thus a complete insensibility to pain. There is great peril attending its use, even in the hands of the most skillful and experienced practitioners. It is sometimes prescribed by a physician, and afterward (as in the case of laudanum, morphine, and chloral) the sufferer, charmed with the release from pain and the peaceful slumber secured, buys the Lethean liquid for himself. Its use soon becomes an apparent necessity. The craving for the narcotic at a stated time is almost irresistible. The patient, compelled to give up the use of chloroform, will demand, entreat, pray for another dose, in a heartrending manner, never to be forgotten. Paleness and debility, the earliest symptoms, are followed by mental prostration. Familiarity with this dangerous drug begets carelessness, and its victims are frequently found dead in their beds, with the handkerchief from which they inhaled the volatile poison clutched in their lifeless hands. 6. COCAINE.