GENERAL EFFECT OF ALCOHOL UPON THE CIRCULATION.--During the experiment described on page 118, the influence of alcohol upon the blood may be beautifully tested. Place on the web of the frog's foot a drop of dilute spirit. The blood vessels immediately expand--an effect known as "_Vascular enlargement_." Channels before unseen open, and the blood disks fly along at a brisker rate. Next, touch the membrane with a drop of pure spirit. The blood channels quickly contract; the cells slacken their speed; and, finally, all motion ceases. The flesh shrivels up and dies. The circulation thus stopped is stopped forever. The part affected will in time slough off. Alcohol has killed it. The influence of alcohol upon the human system is very similar. When strong, as in spirits, it acts as an irritant, narcotic poison (p. 142, note). Diluted, as in fermented liquors, it dilates the blood vessels, quickens the circulation, hastens the heart throbs, and accelerates the respiration. THE EFFECT OF ALCOHOL UPON THE HEART.--What means this rapid flow of the blood? It shows that the heart is overworking. The nerves that lead to the minute capillaries and regulate the passage of the vital current through the extreme parts of the body, are paralyzed by this active narcotic. The tiny blood vessels at once expand. This "Vascular enlargement" removes the resistance to the passage of the blood, and a rapid beating of the heart results. [Footnote: Dr. B. W. Richardson's experiments tend to prove that this apparently stimulating action of alcohol upon the heart is due to the paralysis of the nerves that control the capillaries (Note, p. 208), which ordinarily check the flow of the blood (p. 117). The heart, like other muscles under the influence of alcohol, really loses power, and contracts less vigorously (p. 183). Dr. Palmer, of the University of Michigan, also claimed that alcohol, in fact, diminishes the strength of the heart. Prof. Martin, of Johns Hopkins University, from a series of carefully conducted experiments upon dogs, concluded that blood containing one fourth per cent of alcohol almost invariably diminishes within a minute the work done by the heart; blood containing one half per cent always diminishes it, and may reduce the amount pumped out by the left ventricle so that it is not sufficient to supply the coronary arteries. One hundred years ago, alcohol was always spoken of as a stimulant. Modern experiment and investigation challenged that definition, and it is now classified as a narcotic. There are, however, able physicians who maintain that, taken in small doses, and under certain physical conditions, it has the effect of a stimulant. All agree that, when taken in any amount, it tends to create an appetite for more.]