These poisons also act in the same way as the alkyl chlorides, but the
excitement accompanying the narcosis is more marked—so far as the scanty
observations allow conclusions to be drawn. The symptoms first show
themselves in sickness, giddiness, hebetude, slowing of respiratory
movements and of the heart’s action; convulsions or delirium ensue.
Treatment consists in artificial respiration or promotion of breathing
by a plentiful supply of fresh air or oxygen; in pronounced narcosis
stimulating remedies should be applied.
BENZENE SERIES
_Chlorobenzene_, and _nitro-_ and _dinitro-chlorobenzene_ and
_benzoylchloride_, have given rise to industrial poisoning.
To chlorobenzene similar action is attributed as to benzene (headache,
fainting, rapid breathing, cyanosis); changes in the blood (methæmoglobin
formation) have also been observed.
Nitro- and dinitro-chlorobenzene are active poisons; the effect
corresponds in general to that of nitro- and dinitrobenzene, but in
addition the fumes or dust have markedly irritant action on the skin
(dermatitis).
_Benzoylchloride_ (C₆H₅COCl), a colourless, pungent-smelling liquid,
produces a violently irritant effect upon the mucous membrane,
decomposing into hydrochloric acid and benzoic acid.
Treatment is analogous to that of benzene poisoning, and in cases of
benzoyl chloride poisoning to that by hydrochloric acid.
It may be mentioned that chlorine rash is attributed to the action of
chlorinated tar products (chlorobenzene compounds).
HYDROXYL SUBSTITUTION PRODUCTS
FATTY SERIES (ALCOHOLS)
The hydroxyl substitution products of the fatty series belong mainly
to the narcotic poisons; the greater the molecular weight of the
alcohol, the more marked is usually the narcotic effect. According to
this propylalcohol is eighteen times as poisonous as ethylalcohol;
butylalcohol and amylalcohol have from 36 to 120 times as great a
narcotic effect as methylalcohol.
_Methylalcohol_ (wood spirit, CH₃OH) plays relatively the greatest part
among alcohols as an industrial poison, because it is employed as a
means of denaturing spirit. Its poisonous nature is relatively great,
being very persistent. Industrial poisoning by methylalcohol is due to
inhalation of the vapour and is rarely of a severe nature. The fumes
have a strongly irritant effect upon the mucous membrane, giving rise to
throat irritation, cough, hoarseness, and in severe cases bronchitis and
inflammation of the conjunctiva of the eye. In addition inhalation of
methylalcohol vapour causes headache, giddiness, nausea (inclination to
vomit), and occasionally also twitchings and tremor.
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