A case of chlorobenzene poisoning was reported with symptoms of headache, cyanosis, fainting attacks, difficulty of breathing, &c., in a man who had worked only three weeks with the substance.[6] In the nitrotoluene department of an explosives factory a number of the workmen suffered from symptoms of distress in breathing, headache, &c., of whom two, employed only a short time, died. The poisoning was attributed, partly to nitrotoluene and partly to nitrous fumes. As a contributing cause it was alleged that in view of shortage of hands unsuitable persons were engaged who neglected precautions.[7] Nitronaphthalene is said to cause inflammation and opacity of the cornea,[8] attributable either to long-continued exposure (four to eight months) to nitronaphthalene vapour or to spurting of the liquid into the eye. I could not find reference in literature to actual cases of poisoning by picric acid. They are referred to in a general way only as causing skin affections. Aniline poisoning arises generally from inhalation, but absorption through the skin and less frequently inhalation of dust of aniline compounds cause it. We have already laid stress on the frequently severe cases resulting from carelessness in spilling on to or splashing of, clothes without at once changing them, breaking of vessels containing it, and entering vessels filled with the vapour. In literature of old date many such cases have been described, and it was stated that workers were especially affected on hot days, when almost all showed cyanosis. Such observations do not state fairly the conditions to-day in view of the improvements which Grandhomme and Leymann’s observations show have taken place in aniline factories. Still, cases are fairly frequent. Thus in a factory with 251 persons employed, thirty-three cases involving 500 days of sickness were reported. The Report of the Union of Chemical Industry for 1907 cites the case of a worker who was tightening up the leaky wooden bung of a vessel containing aniline at a temperature of 200° C. He was splashed on the face and arms, and although the burns were not in themselves severe he died the next day from aniline absorption. Cases of anilism are not infrequent among dyers. The reports of the Swiss factory inspectors for 1905 describe a case where a workman worked for five hours in clothes on to which aniline had spurted when opening an iron drum. Similar cases are described in the report of the English factory inspectors for the same year. Aniline black dyeing frequently gives rise to poisoning, and to this Dearden[9] of Manchester especially has called attention.