It seems quite certain that deaths from organic diseases of the heart increase during and following influenza epidemics and are due probably to the inability of the weakened patients to resist the added burden. Fränkel and Dublin found an increase in deaths from this cause. This was also observed to be true in Spain and other localities. Jordan has compared the curves of influenza with those of acute coryza among school children of Chicago and finds that the period of highest incidence of colds in October, 1918, occurred in the second week of school and that it preceded the corresponding period of influenza by seven weeks. There were three peaks in the curve for colds and only two in that for influenza. The period of highest incidence of colds follows the first peak of the influenza curve by one week, while during the week of greatest prevalence of influenza there is a sharp fall of the number of cases of colds. The third peak for colds occurred one week after the height of the influenza curve. As a rule the colds curve runs at a higher level than that for influenza. A striking fact is that the portion of the curve for influenza contained within the period November 23d to December 7th, is almost the exact opposite of the corresponding portion in the curve for colds. How much of this is due to the factor of diagnosis is difficult to say. _Encephalitis lethargica._—It is not within the scope of our report to discuss in detail this disease. Its apparent relationship with influenza, in point of time, if not otherwise, calls for special mention. In 1712 a disease followed a pandemic of influenza, occurring particularly in Germany, where it was known under the name of “Tübingen Sleeping Sickness.” In the spring of 1890, according to Netter, a disease of similar character called “Nona” was distributed especially in Northern Italy and Hungary and scattered more or less diffusely over a large part of Europe. Preceding the last influenza pandemic the disease was first reported in Vienna in the winter of 1916–17. Cases were seen in Paris in February and March, 1918, and the first official report of the disease in England seems to have been on January 26, 1918. In the spring of 1918 there were 168 officially reported cases in England with 37 deaths. The disease seems to have disappeared there in June, 1918, and reappeared in the autumn of the same year. The first cases in the United States were reported by Pothier at Camp Lee, Va. Following the great influenza pandemic cases of lethargic encephalitis have appeared in all parts of the world. It has been present in England, France, Belgium, Switzerland, Austria, Greece, Italy, and other countries of Europe, South America, Mexico, the United States, Australia, Queensland, New South Wales, and Algiers. There was an increase of encephalitis lethargica concomitant with the increase of influenza in the early months of 1920. Thus, in Switzerland 440 cases were reported during February, 1920.