In the next place, I have to observe that in all my experiments I tried, as he subsequently tried, both kinds of stimulation, and also the constant current; but I soon found that even when one went to work with one's ideas upon the subject in a non-inverted position, no trustworthy inference could be drawn in favour of the muscular elements alone remaining uninjured from the bare fact that after the poisoning the neuro-muscular tissue often behaved differently towards different kinds of stimulation. Further, in the particular case of my experiments with curare--against which Dr. Krukenberg's remarks are chiefly directed on the ground that I did not prove the paralysis to be a merely muscular effect--I succeeded in obtaining very much better proof of the poison acting on the nervous elements, to the exclusion of the muscular, than I could have obtained by any process of inference, however good; that is to say, I obtained direct proof. It appears to me that Dr. Krukenberg must have failed to understand the English of the following sentences: "On nipping any portion of the poisoned half of Staurophora laciniata, this half remained _absolutely motionless_, while the unpoisoned half, _though far away from the seat of irritation_, immediately ceased its normal contractions, and folded itself together in the very peculiar and distinctive manner just described," _i.e._ "in one very strong and long-protracted systole." For the rest, see note on page 232. Lastly, while again expressing my satisfaction that on all matters of fact, our results are in full harmony, I may be allowed to remark that in my opinion his deductions, as embodied in his schema of the inferred innervation of Medusæ, are very far in advance of anything that is justified by observation. (See, for this elaborate schema, in which there are represented volitional, motor, reflex, and inhibitory centres, as well as a clearly defined system of sensory and motor nerves, "Vergleichend-Physiologogische Studien, dritte Abtheiling," p. 141: Heidelberg, 1880.) _Physiological Effects of Fresh Water on the Medusæ_