The two had met at a "blind tiger" saloon in Jackson and quarreled, with the result that both drew their pistols and fired upon each other. Before Hargis sank dying to the floor, he had succeeded in seriously wounding his antagonist. The Hargises at once began an active prosecution of Cockrell and kept it up. Dr. Cox had married a kinswoman of the Cockrell boys and had also become their guardian, both of them being under age. The Cockrells were also related to Marcum, who had volunteered in Tom Cockrell's defense for the killing of Ben Hargis. Marcum also was an intimate friend of Dr. Cox, who practised in Jackson and vicinity. Not long after the killing of Ben Hargis another brother of Judge Hargis met his death at the hands of a man charged by the Hargis clan as being a Cockrell man. John Hargis was the man slain; "Tige" was his nickname. He was killed by Jerry Cardwell. Hargis had boarded the train at Jackson on his way to Beattyville. Cardwell was the train detective. It is claimed that Hargis had been drinking and became disorderly. The conductor in charge of the train asked Cardwell to preserve the peace. As soon as Cardwell entered the car Hargis sprang to his feet and drew his gun. Cardwell and he fired simultaneously. Cardwell was wounded, Hargis shot through the heart. The Hargis clan always claimed that the killing of John Hargis was the issue of a well-laid conspiracy with the Cockrells at the bottom of it. They attempted to connect them with the shooting, but nothing ever came of it. Dr. Cox, guardian and kinsman of the Cockrell boys, and J. B. Marcum, their cousin, were intimate friends and frequently discussed the foreboding aspect the community was taking on. Rumors came to them frequently now that they were marked for assassination. At first neither Dr. Cox nor Marcum gave them much credence. Finally, about the first of April, 1901, Marcum went to Washington on business. While there, Dr. Cox was assassinated. Marcum was convinced that he, too, was marked for death. The proof in the case shows that Dr. Cox had left his home about eight o'clock one night to make a professional call. The conspirators had for many nights been watching his movements. He had almost reached the corner of the street diagonally across from the court house, and directly opposite Judge Hargis' stable, when he was fired on and he fell dead, riddled with small shot. After he had fallen to the ground the assassins fired another volley into his body and easily escaped. There was persistent rumor at the time of the killing that the shots had been fired from Hargis' stable, but witnesses were afraid to swear positively about anything. Indictments against parties for the murder were not returned until some time afterwards. It has been told that Judge Hargis had been heard to laughingly say, after the fall of Dr. Cox, "Great Scot! didn't he bellow like a bull when that shot hit him?"